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Rapid Water Permeation by Aramid Foldamer Nanochannels With Hydrophobic Interiors
Author(s) -
Farooq Saquib,
Malla Javid Ahmad,
Nedyalkova Miroslava,
Freire Rafael V. M.,
Mandal Indradip,
Crochet Aurelien,
Salentinig Stefan,
Lattuada Marco,
McTernan Charlie T.,
Kilbinger Andreas F. M.
Publication year - 2025
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202504170
Subject(s) - permeation , aramid , foldamer , chemistry , polymer chemistry , chemical engineering , membrane , polymer science , organic chemistry , stereochemistry , biochemistry , engineering , fiber
Abstract Aquaporins are natural proteins that rapidly transport water across cell membranes, maintaining homeostasis, whilst strictly excluding salt. This has inspired their use in water purification and desalination, a critical emerging need. However, stability, scalability, and cost have prevented their widespread adoption in water purification membrane technologies. As such, attention has turned to the use of artificial water channels, with pore‐functionalized polymers and macrocycles providing a powerful alternative. Whilst impressive rates of transport have been achieved, the combination of a scalable, high‐yielding synthesis and efficient transport has not yet been reported. Herein, we report such a system, with densely functionalized channel interiors, synthesized by high‐yielding living polymerization with low polydispersities, showing high salt exclusion and excellent water transport rates. Our aramid foldamers create artificial water channels with hydrophobic interiors and single‐channel water permeability rates of up to 10 8 water molecules per second per channel, approaching the range of natural aquaporins (c. 10 9 ). We show that water transport rates closely correspond to the helical length, with the polymer that most closely matches bilayer thickness showing optimal efficacy, as supported by molecular dynamics (MD) simulations. Our work provides a basis for the scalable synthesis of next‐generation artificial water channels.