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Enantioselective Spirocyclization of Pd‐Enolates and Isocyanates
Author(s) -
Barbor Jay P.,
Flesch Kaylin N.,
Chan Melinda,
Ang Hannah R.,
Stoltz Brian M.
Publication year - 2025
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202502583
Subject(s) - enantioselective synthesis , chemistry , organic chemistry , polymer chemistry , catalysis
Abstract An enantioselective cyclization of Pd‐enolates and isocyanates to form spirocyclic γ‐lactams is reported. This reaction proceeds under mild reaction conditions and utilizes a novel Meldrum's acid derivative to achieve catalyst turnover, delivering enantioenriched products in up to 97% yield and 96% ee. Preliminary mechanistic investigations suggest that the reaction may proceed via the formation of higher‐order species.
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