Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes | Zendy

Si Yafeng | Zendy; Liu Yuntao | Zendy; Zhou Fan | Zendy; Fang Lei | Zendy; Wu Kang | Zendy; Luan YuXin | Zendy; Chen Li | Zendy; Tang Pingping | Zendy

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Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes

Author(s) -

Si Yafeng,

Liu Yuntao,

Zhou Fan,

Fang Lei,

Wu Kang,

Luan YuXin,

Chen Li,

Tang Pingping

Publication year - 2025

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.202501680

Subject(s) - enantioselective synthesis , cobalt , catalysis , chemistry , alkene , organic chemistry , combinatorial chemistry

Abstract The construction of optically pure benzyl trifluoromethoxy (OCF 3 ) compounds continues to present challenges due to limited enantioselectivity‐control or the necessity for OCF 3 ‐containing substrates in the only two previous reports. Herein, we have developed a salen‐Co‐catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.

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