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“Naked Nickel”‐Catalyzed Heteroaryl–Heteroaryl Suzuki–Miyaura Coupling
Author(s) -
Saeb Rakan,
Roh Byeongdo,
Cornella Josep
Publication year - 2025
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202424051
Subject(s) - nucleophile , catalysis , chemistry , nickel , combinatorial chemistry , decomposition , coupling reaction , medicinal chemistry , organic chemistry
Abstract In this article, we report that the air‐stable “naked nickel”, [Ni( 4‐CF3 stb) 3 ], is a competent catalyst in the catalytic Suzuki–Miyaura cross‐coupling reaction (SMC) between heteroaryl bromides and heteroaromatic boron‐based nucleophiles. The catalytic system is characterized by its ability to avoid decomposition or deactivation in the presence of multiple Lewis basic sites. The protocol permits the formation of C‒C bonds between two heteroaryl moieties in the absence of complex exogenous ligands, thus minimizing screening procedures and simplifying reaction setups. This method accommodates combinations of distinct 6‐membered heteroaryl bromides and 5‐ and 6‐membered heterocyclic B ‐based nucleophiles.