Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population (Adv. Sci. 20/2025) | Zendy

Chen Banru | Zendy; Guan Lizhi | Zendy; Wu Chao | Zendy; Gong Yiwen | Zendy; Wu Lei | Zendy; Zhang Minchun | Zendy; Cao Zhiwen | Zendy; Chen Yufei | Zendy; Yang Chengcan | Zendy; Wang Bing | Zendy; Li Yunqi | Zendy; Li Bin | Zendy; Bi Yufang | Zendy; Ning Guang | Zendy; Wang Jiqiu | Zendy; Wang Weiqing | Zendy; Liu Ruixin | Zendy

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Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population (Adv. Sci. 20/2025)

Author(s) -

Chen Banru,

Guan Lizhi,

Wu Chao,

Gong Yiwen,

Wu Lei,

Zhang Minchun,

Cao Zhiwen,

Chen Yufei,

Yang Chengcan,

Wang Bing,

Li Yunqi,

Li Bin,

Bi Yufang,

Ning Guang,

Wang Jiqiu,

Wang Weiqing,

Liu Ruixin

Publication year - 2025

Publication title -

advanced science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.388

H-Index - 100

ISSN - 2198-3844

DOI - 10.1002/advs.202570151

Gut Microbiota‐Butyrate‐PPARγ This study demonstrates that gut microbiota‐derived butyrate promotes adipose ST2 + regulatory T cell population through PPARγ activation. The cover illustration depicts gut microbiota (represented by orange‐shaped bacterial cells) releasing butyrate (represented as blue particles and blue molecular structures), which transmit electrical‐like signals to activate ST2 + regulatory T cells (shown in purple) in adipose tissue (orange cells), highlighting their role in maintaining adipose tissue immune homeostasis. More details can be found in article number 2411086 by Weiqing Wang, Ruixin Liu, and co‐workers. Cover design by Rui Xie.

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