Open AccessALKBH3‐Mediated M 1 A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M 1 A and M 6 A RNA Methylation (Adv. Sci. 19/2025)
Author(s) -
Tu Liying,
Gu Shuchen,
Xu Ruoqing,
Yang En,
Huang Xin,
Liang Hsin,
Luo Shenying,
Li Haizhou,
Zhao Yixuan,
Zan Tao
Publication year - 2025
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202570146
Pathological Skin Fibrosis The artwork symbolises RNA modification crosstalk in skin fibrosis through Medusa and Perseus. Medusa's gaze symbolizing m 6 A methylation promotes fibrotic progression and transforms healthy skin into a rigid stone‐like state. Perseus representing m 1 A methylation neutralizes this effect by reflecting her gaze and thereby inhibits fibrosis. This visual metaphor underscores m 6 A's detrimental role and m 1 A's protective function in fibrosis. More details can be found in article number 2417067 by Haizhou Li, Yixuan Zhao, Tao Zan, and co‐workers.