Open AccessArtificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation (Adv. Sci. 19/2025)
Author(s) -
Zhao Long,
Shi Zhen,
Zhang Xiaoyu,
Wang Jingting,
Yang Shang,
Wang Fuyan,
Li Tan,
Zhou Qingjun,
Wang Ting,
Shi Weiyun
Publication year - 2025
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202570140
Artificial Cornea Substitutes In article number 2411540, Qingjun Zhou, Ting Wang, Weiyun Shi, and co‐workers present a humanized corneal substitute using porcine‐cornea templated hydrogel skeletons infused with human ECM and GelMA, achieving light‐activated adhesion. By replicating native stromal hierarchy, it possesses optical/mechanical properties similar to those of natural corneas, and promotes epithelial regeneration and stromal integration. It offers a promising solution to donor shortages and transplant complications.