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Nickel‐Catalyzed Cyanation of Vinyl Triflates with Isonitrile as a Nucleophilic CN Source
Author(s) -
Hu Yuntong,
Qin Jian,
Zhu Shengqing,
Chu Lingling
Publication year - 2025
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202500200
Subject(s) - chemistry , cyanation , nickel , catalysis , nucleophile , medicinal chemistry , organic chemistry , combinatorial chemistry
Abstract We report a nickel‐catalyzed cyanation of vinyl triflates using tert ‐butyl isonitrile as a nucleophilic CN source. This reaction employs simple Ni(OTf) 2 as the catalyst, operating without exogenous ligands or reductants. The method enables selective and efficient access to a broad range of cyclic and acyclic alkenyl nitriles, accommodating diverse functional groups and substrates, including natural products and pharmaceuticals.
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