Visible‐light‐induced Difunctionalization of Styrenes with 4‐cyanopyridines and Thioacetates or Thiosulfonates | Zendy

Wang Jinsong | Zendy; Jin Chengliu | Zendy; Chen Jialin | Zendy; Song Yingming | Zendy; Huang Jianmin | Zendy; Zhu Baofu | Zendy; Cao Hua | Zendy; He Qiuxing | Zendy; Yu Yue | Zendy

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Visible‐light‐induced Difunctionalization of Styrenes with 4‐cyanopyridines and Thioacetates or Thiosulfonates

Author(s) -

Wang Jinsong,

Jin Chengliu,

Chen Jialin,

Song Yingming,

Huang Jianmin,

Zhu Baofu,

Cao Hua,

He Qiuxing,

Yu Yue

Publication year - 2025

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202500041

Subject(s) - chemistry , photochemistry , polymer chemistry

Abstract Simultaneous thiolation/pyridinylation of alkenes was achieved in a three‐component reaction under visible‐light‐induced conditions. By employing 4CzIPN as a photocatalyst and DIPEA as a base, a variety of alkenes and cyanopyridines reacted well with thioacetates or thiosulfonates to obtain the difunctionalized products in excellent yields with high regio‐selectivity. The thiolation/pyridinylation products could easily transfer to 4‐(1‐phenylvinyl)pyridine or dithioperoxoate compounds. Furthermore, the in vitro antitumor activities of selected compounds were screened through MTT assay and the results showed that compound 6 e exhibited similar antitumor activity with 5‐fluorouracil (5‐FU).

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