Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation

Abstract Hair loss affects millions globally, creating a demand for safer, more effective treatments. Traditional treatments like minoxidil often have limited efficacy and side effects. This study explores tannic acid, a polyphenol, as a promising alternative, serving as a multifaceted adhesion mediator that binds to keratin on the hair surface and serves as a reservoir for functional molecules‐salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL)‐collectively termed SCANDAL . Tannic acid forms a stable coating on hair through hydrogen bonding, while its unbound phenolic sites sequester SCANDAL molecules, enabling their controlled release upon exposure to moisture. This gradual release delivers active molecules directly to hair follicles, enhancing hair health and mitigating hair loss. In a seven‐day study with 12 human participants, an average reduction of 56.2 ± 18.2% in the number of shed hairs is observed compared to their baseline counts. The presence of tannic acid on the hair surface is confirmed via X‐ray photoelectron spectroscopy (XPS), and the formation of tannic acid/SCANDAL complexes is visualized using transmission electron microscopy (TEM). This approach demonstrates that hair keratin surfaces can serve as large‐area platforms for controlled release of therapeutic agents, addressing various challenges in hair and scalp health.