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Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting (Adv. Funct. Mater. 21/2025)
Author(s) -
Wang Zixun,
Zhao Xi,
Chan WanMui,
Ji Xianglin,
Huang Linfeng,
Xie Xi,
Li Wei,
Zhang Wenjun,
To Kelvin KaiWang,
Shi Peng
Publication year - 2025
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202570125
NanoPick Array In article number 2310157, Kelvin Kai‐Wang To, Peng Shi, and co‐workers develop a biochip with vertically aligned nanostructures, NanoPick‐array, for rapid analysis of viral RNAs. The platform combines selective short‐cut of viral RNAs, cherry‐picking isolation of target genes, and micro‐arrayed discrete nanoimaging to enable the detection of COVID‐19 RNAs without the need for amplification and sequencing, providing the capability to differentiate single‐nucleotide genetic mutation among different viral variants.