Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness
Author(s) -
Weiqiu Cheng,
Oleksandr Frei,
Dennis van der Meer,
Yunpeng Wang,
Kevin S. O’Connell,
Yunhan Chu,
Shahram Bahrami,
Alexey Shadrin,
Dag Alnæs,
Guy Hindley,
Aihua Lin,
Naz Karadag,
Chun-Chieh Fan,
Lars T. Westlye,
Tobias Kaufmann,
Espen Molden,
Anders M. Dale,
Srdjan Djurovic,
Olav B. Smeland,
Ole A. Andreassen
Publication year - 2021
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2021.1435
Subject(s) - schizophrenia (object oriented programming) , genome wide association study , genetic architecture , biology , genomics , false discovery rate , biobank , genetics , genetic association , multifactorial inheritance , single nucleotide polymorphism , medicine , genome , quantitative trait locus , psychiatry , gene , genotype
Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive.
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