Human Papillomavirus Genotype Detection in Oral Gargle Samples Among Men With Newly Diagnosed Oropharyngeal Squamous Cell Carcinoma | Zendy

Laura MartinGomez | Zendy; Anna R. Giuliano | Zendy; William J. Fulp | Zendy; Jimmy J. Caudell | Zendy; M. Echevarria | Zendy; Bradley Sirak | Zendy; Martha Abrahamsen | Zendy; Kimberly IsaacsSoriano | Zendy; Juan C. HernandezPrera | Zendy; Bruce M. Wenig | Zendy; Kathryn M. Vorwald | Zendy; Caitlin McMullen | Zendy; J. Trad Wadsworth | Zendy; Robbert J.C. Slebos | Zendy; Christine H. Chung | Zendy

Open Access

Human Papillomavirus Genotype Detection in Oral Gargle Samples Among Men With Newly Diagnosed Oropharyngeal Squamous Cell Carcinoma

Author(s) -

Laura MartinGomez,

Anna R. Giuliano,

William J. Fulp,

Jimmy J. Caudell,

M. Echevarria,

Bradley Sirak,

Martha Abrahamsen,

Kimberly IsaacsSoriano,

Juan C. HernandezPrera,

Bruce M. Wenig,

Kathryn M. Vorwald,

Caitlin McMullen,

J. Trad Wadsworth,

Robbert J.C. Slebos,

Christine H. Chung

Publication year - 2019

Publication title -

jama otolaryngology–head and neck surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.571

H-Index - 128

eISSN - 2168-619X

pISSN - 2168-6181

DOI - 10.1001/jamaoto.2019.0119

Subject(s) - genotype , human papillomavirus , basal cell , medicine , koilocyte , oncology , biology , cancer , gene , genetics , cervical cancer , cervical intraepithelial neoplasia

The most common cause of oropharyngeal squamous cell carcinoma is human papillomavirus (HPV) infection, and currently the standard of care to determine the HPV infection status in this type of carcinoma is to use p16 immunohistochemistry as a surrogate marker of high-risk HPV infection. Although p16 immunohistochemistry is limited by the inability to determine the specific HPV genotypes, oral gargle samples may be a readily available source of HPV DNA for genotyping.

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