Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding
Author(s) -
Marie Deen,
Anders Hougaard,
Hanne D. Hansen,
Martin Schain,
Agnete Dyssegaard,
Gitte M. Knudsen,
Messoud Ashina
Publication year - 2019
Publication title -
jama neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.298
H-Index - 231
eISSN - 2168-6157
pISSN - 2168-6149
DOI - 10.1001/jamaneurol.2019.0755
Subject(s) - sumatriptan , migraine , triptans , migraine with aura , aura , migraine treatment , medicine , anesthesia , 5 ht receptor , cortical spreading depression , receptor , serotonin , agonist
Triptans, the most efficient acute treatment for migraine attacks, are 5-HT1B/1D receptor agonists, but their precise mechanism of action is not completely understood. The extent to which triptans enter the central nervous system and bind to 5-HT1B receptors in the brain is unknown.
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