Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring | Zendy

Jakob Christensen | Zendy; Lars Pedersen | Zendy; Yuelian Sun | Zendy; Julie Werenberg Dreier | Zendy; Isabell Brikell | Zendy; Søren Dalsgaard | Zendy

Open Access

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring

Author(s) -

Jakob Christensen,

Lars Pedersen,

Yuelian Sun,

Julie Werenberg Dreier,

Isabell Brikell,

Søren Dalsgaard

Publication year - 2019

Publication title -

jama network open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.278

H-Index - 39

ISSN - 2574-3805

DOI - 10.1001/jamanetworkopen.2018.6606

Subject(s) - medicine , attention deficit hyperactivity disorder , hazard ratio , pediatrics , pregnancy , offspring , interquartile range , cohort study , cohort , population , psychiatry , confidence interval , environmental health , biology , genetics

Key Points Question What is the risk of attention-deficit/hyperactivity disorder in children prenatally exposed to valproate and other antiepileptic drugs? Findings In a population-based cohort study of 913 302 children in Denmark, prenatal exposure to valproate was significantly associated with a 48% increased risk of attention-deficit/hyperactivity disorder compared with children with no valproate exposure. No association was identified for other antiepileptic drugs. Meaning The findings of this study corroborate that counseling is appropriate for the use of valproate in pregnancy and in women of childbearing potential.

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