Use of Topical Glycolic Acid Plus a Lovastatin-Cholesterol Combination Cream for the Treatment of Autosomal Recessive Congenital Ichthyoses | Zendy

Samar Khalil | Zendy; Tara Bardawil | Zendy; Serena Saade | Zendy; Adele Chedraoui | Zendy; Nehmat Ramadan | Zendy; Divina Justina Hasbani | Zendy; Ossama Abbas | Zendy; Georges Nemer | Zendy; Nelly Rubeiz | Zendy; Mazen Kurban | Zendy

Open Access

Use of Topical Glycolic Acid Plus a Lovastatin-Cholesterol Combination Cream for the Treatment of Autosomal Recessive Congenital Ichthyoses

Author(s) -

Samar Khalil,

Tara Bardawil,

Serena Saade,

Adele Chedraoui,

Nehmat Ramadan,

Divina Justina Hasbani,

Ossama Abbas,

Georges Nemer,

Nelly Rubeiz,

Mazen Kurban

Publication year - 2018

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2018.2904

Subject(s) - medicine , glycolic acid , dermatology , regimen , lovastatin , lamellar ichthyosis , acne , statin , ichthyosis , surgery , cholesterol , lactic acid , genetics , bacteria , biology

Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of disorders caused by defects in signaling pathways involved in epidermal proliferation and differentiation, leading to a wide range of skin manifestations. Therapeutic options are limited and often unsatisfactory. Topical cholesterol and statin as a combined formulation has proven successful in the treatment of patients with CHILD syndrome (congenital hemidysplasia ichthyosis and limb defects).

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