Tropomyosin Receptor Kinase A Expression on Merkel Cell Carcinoma Cells | Zendy

Ulrike Wehkamp | Zendy; Sophie Stern | Zendy; Sandra Krüger | Zendy; Axel Hauschild | Zendy; Christoph Röcken | Zendy; Friederike Egberts | Zendy

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Tropomyosin Receptor Kinase A Expression on Merkel Cell Carcinoma Cells

Author(s) -

Ulrike Wehkamp,

Sophie Stern,

Sandra Krüger,

Axel Hauschild,

Christoph Röcken,

Friederike Egberts

Publication year - 2017

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2017.2495

Subject(s) - medicine , merkel cell carcinoma , tropomyosin , merkel cell , cancer research , receptor , carcinoma , pathology , microbiology and biotechnology , actin , biology

Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor frequently associated with the Merkel cell polyomavirus. Immune checkpoint therapy showed remarkable results, although not all patients are responsive to this therapy. Anti-tropomyosin receptor kinase A (TrkA)-targeted treatment has shown promising results in several tumor entities.

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