Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma | Zendy

Pritesh S. Karia | Zendy; Frederick Morgan | Zendy; Emily S. Ruiz | Zendy; Chrysalyne D. Schmults | Zendy

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Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma

Author(s) -

Pritesh S. Karia,

Frederick Morgan,

Emily S. Ruiz,

Chrysalyne D. Schmults

Publication year - 2017

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2017.1680

Subject(s) - medicine , perineural invasion , disease , oncology , medline , cancer , dermatology , political science , law

Perineural invasion (PNI) in cutaneous squamous cell carcinoma (CSCC) has been associated with an increased risk of poor outcomes. Patients with PNI may present with clinical symptoms and/or radiologic evidence of PNI (clinical PNI [CPNI]), yet most patients are asymptomatic and PNI is often found on histologic examination (incidental PNI [IPNI]). Evidence-based estimates of the risks of disease-related outcomes comparing IPNI and CPNI are limited in the dermatology literature.

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