Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular Disease
Author(s) -
Sabina A. Murphy,
Terje R. Pedersen,
Zbigniew Gaciong,
R Češka,
М. В. Ежов,
Derek Connolly,
J. Wouter Jukema,
Kálmán Tóth,
Matti J. Tikkanen,
Canqing Yu,
Stephen D. Wiviott,
Christopher E. Kurtz,
Narimon Honarpour,
Robert P. Giugliano,
Anthony Keech,
Peter Sever,
Marc S. Sabatine
Publication year - 2019
Publication title -
jama cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.108
H-Index - 63
eISSN - 2380-6591
pISSN - 2380-6583
DOI - 10.1001/jamacardio.2019.0886
Subject(s) - medicine , evolocumab , pcsk9 , hazard ratio , clinical endpoint , alirocumab , myocardial infarction , unstable angina , cardiology , placebo , stroke (engine) , discontinuation , statin , surrogate endpoint , clinical trial , cholesterol , confidence interval , lipoprotein , mechanical engineering , ldl receptor , alternative medicine , apolipoprotein a1 , pathology , engineering
The PCSK9 inhibitor evolocumab reduced low-density lipoprotein cholesterol and first cardiovascular events in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, but patients remain at high risk of recurrent cardiovascular events.
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