Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients | Zendy

Wataru Shimizu | Zendy; Hisaki Makimoto | Zendy; Kenichiro Yamagata | Zendy; Tsukasa Kamakura | Zendy; Mitsuru Wada | Zendy; Koji Miyamoto | Zendy; Yuko InoueYamada | Zendy; Hideo Okamura | Zendy; Kohei Ishibashi | Zendy; Takashi Noda | Zendy; Satoshi Nagase | Zendy; Aya Miyazaki | Zendy; Heima Sakaguchi | Zendy; Isao Shiraishi | Zendy; Takeru Makiyama | Zendy; Seiko Ohno | Zendy; Hideki Itoh | Zendy; Hiroshi Watanabe | Zendy; Kenshi Hayashi | Zendy; Masakazu Yamagishi | Zendy; Hiroshi Morita | Zendy; Masao Yoshinaga | Zendy; Yoshiyasu Aizawa | Zendy; Kengo Kusano | Zendy; Yoshihiro Miyamoto | Zendy; Shiro Kamakura | Zendy; Satoshi Yasuda | Zendy; Hisao Ogawa | Zendy; Toshihiro Tanaka | Zendy; Naotaka Sumitomo | Zendy; Nobuhisa Hagiwara | Zendy; Keiichi Fukuda | Zendy; Satoshi Ogawa | Zendy; Yoshifusa Aizawa | Zendy; Naomasa Makita | Zendy; Tohru Ohe | Zendy; Minoru Horie | Zendy; Takeshi Aiba | Zendy

Open Access

Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients

Author(s) -

Wataru Shimizu,

Hisaki Makimoto,

Kenichiro Yamagata,

Tsukasa Kamakura,

Mitsuru Wada,

Koji Miyamoto,

Yuko InoueYamada,

Hideo Okamura,

Kohei Ishibashi,

Takashi Noda,

Satoshi Nagase,

Aya Miyazaki,

Heima Sakaguchi,

Isao Shiraishi,

Takeru Makiyama,

Seiko Ohno,

Hideki Itoh,

Hiroshi Watanabe,

Kenshi Hayashi,

Masakazu Yamagishi,

Hiroshi Morita,

Masao Yoshinaga,

Yoshiyasu Aizawa,

Kengo Kusano,

Yoshihiro Miyamoto,

Shiro Kamakura,

Satoshi Yasuda,

Hisao Ogawa,

Toshihiro Tanaka,

Naotaka Sumitomo,

Nobuhisa Hagiwara,

Keiichi Fukuda,

Satoshi Ogawa,

Yoshifusa Aizawa,

Naomasa Makita,

Tohru Ohe,

Minoru Horie,

Takeshi Aiba

Publication year - 2019

Publication title -

jama cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.108

H-Index - 63

eISSN - 2380-6591

pISSN - 2380-6583

DOI - 10.1001/jamacardio.2018.4925

Subject(s) - medicine , long qt syndrome , proband , genotype , family history , qt interval , pediatrics , retrospective cohort study , genetics , gene , mutation , biology

Long QT syndrome (LQTS) is caused by several ion channel genes, yet risk of arrhythmic events is not determined solely by the responsible gene pathogenic variants. Female sex after adolescence is associated with a higher risk of arrhythmic events in individuals with congenital LQTS, but the association between sex and genotype-based risk of LQTS is still unclear.

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