Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke | Zendy

Arturo Renú | Zendy; Mònica Millán | Zendy; Luís San Román | Zendy; Jordi Blasco | Zendy; Joan MartíFàbregas | Zendy; Mikel Terceño | Zendy; Sergio Amaro | Zendy; Joaquı́n Serena | Zendy; Xabier Urra | Zendy; Carlos Laredo | Zendy; Roger Barranco | Zendy; Pol CampsRenom | Zendy; Federico Zarco | Zendy; Laura Oleaga | Zendy; Pere Cardona | Zendy; Carlos Castaño | Zendy; Juan Macho | Zendy; Elisa CuadradoGodia | Zendy; Elío Vivas | Zendy; Antonio LópezRueda | Zendy; Léopoldo Guimaraens | Zendy; Anna RamosPachón | Zendy; Jaume Roquer | Zendy; Marián Muchada | Zendy; Alejandro Tomasello | Zendy; Antonio Dávalos | Zendy; Ferrán Torres | Zendy; Ángel Chamorro | Zendy; Laura Llull | Zendy; Martha Vargas | Zendy; Vı́ctor Obach | Zendy; Salvatore Rudilosso | Zendy; Alejandro Rodríguez-Vázquez | Zendy; Daniel Santana | Zendy; Napoleón Macías | Zendy; Elena Serrano | Zendy; Javier Moreno | Zendy; Natàlia Pérez de la Ossa | Zendy; Laura Dorado | Zendy; María HernándezPérez | Zendy; Meritxell Gomis | Zendy; Lucía Muñoz-Narbona | Zendy; P. Rodríguez-Molinos | Zendy; Martí Boix | Zendy; Ernest Palomeras | Zendy; Fidel Ángel Núñez | Zendy; Sebastián Remollo | Zendy; Mariano Werner | Zendy; Victor Vera | Zendy; Laura Paúl | Zendy; Laura Pardo | Zendy; Montserrat Reina | Zendy; Saima Bashir | Zendy; Ursula Bojaryn | Zendy; Yolanda Silva | Zendy; M. Dolors Millan i Guasch | Zendy; Alan Murillo | Zendy; Juan ÁlvarezCienfuegos | Zendy; María Esteve | Zendy; B. Martínez | Zendy; Erika Nogué | Zendy; Óscar Chirife | Zendy; Helena Quesada | Zendy; Blanca Lara | Zendy; Andrés Paipa | Zendy; Lucía Aja | Zendy; Paloma Mora | Zendy; Maria Angel de Miquel | Zendy; Sònia Aixut | Zendy; Anna Maria Ferrer | Zendy; Rebeca Marín | Zendy; Luís PratsSánchez | Zendy; Raquel DelgadoMederos | Zendy; Alejandro MartínezDomeño | Zendy; J. Branera | Zendy; Rodrigo Guerrero | Zendy; J Villalba | Zendy; Alejandro Rodríguez | Zendy; N. Berga | Zendy; Elena JiménezXarrié | Zendy; Gemma Romeral | Zendy; Ángel Ois | Zendy; Jordi Jiménez | Zendy; Carla Avellaneda-Gómez | Zendy; Núria Cayuela | Zendy; Ana Belén Rodríguez | Zendy; Eva Giralt | Zendy; Merçè Espona | Zendy; J. Saldaña | Zendy; David Hernández | Zendy; Marc Ribó | Zendy; Carlos Piñana | Zendy; Noelia Rodríguez | Zendy; Sandra Boned | Zendy; Carlos A. Molina | Zendy; Marta Rubiera | Zendy; Jesús Juega | Zendy; David RodríguezLuna | Zendy; Juan Pagola | Zendy; Alvaro Garcia-Tonel | Zendy; Matías Deck | Zendy; V. Sala | Zendy; Estela Sanjuán | Zendy; K. Santana | Zendy; C. Losada | Zendy; Pilar Suñé | Zendy; Tudor Jovin | Zendy; Enrique C. Leira | Zendy; José Ríos | Zendy

Open Access

Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke

Author(s) -

Arturo Renú,

Mònica Millán,

Luís San Román,

Jordi Blasco,

Joan MartíFàbregas,

Mikel Terceño,

Sergio Amaro,

Joaquı́n Serena,

Xabier Urra,

Carlos Laredo,

Roger Barranco,

Pol CampsRenom,

Federico Zarco,

Laura Oleaga,

Pere Cardona,

Carlos Castaño,

Juan Macho,

Elisa CuadradoGodia,

Elío Vivas,

Antonio LópezRueda,

Léopoldo Guimaraens,

Anna RamosPachón,

Jaume Roquer,

Marián Muchada,

Alejandro Tomasello,

Antonio Dávalos,

Ferrán Torres,

Ángel Chamorro,

Laura Llull,

Martha Vargas,

Vı́ctor Obach,

Salvatore Rudilosso,

Alejandro Rodríguez-Vázquez,

Daniel Santana,

Napoleón Macías,

Elena Serrano,

Javier Moreno,

Natàlia Pérez de la Ossa,

Laura Dorado,

María HernándezPérez,

Meritxell Gomis,

Lucía Muñoz-Narbona,

P. Rodríguez-Molinos,

Martí Boix,

Ernest Palomeras,

Fidel Ángel Núñez,

Sebastián Remollo,

Mariano Werner,

Victor Vera,

Laura Paúl,

Laura Pardo,

Montserrat Reina,

Saima Bashir,

Ursula Bojaryn,

Yolanda Silva,

M. Dolors Millan i Guasch,

Alan Murillo,

Juan ÁlvarezCienfuegos,

María Esteve,

B. Martínez,

Erika Nogué,

Óscar Chirife,

Helena Quesada,

Blanca Lara,

Andrés Paipa,

Lucía Aja,

Paloma Mora,

Maria Angel de Miquel,

Sònia Aixut,

Anna Maria Ferrer,

Rebeca Marín,

Luís PratsSánchez,

Raquel DelgadoMederos,

Alejandro MartínezDomeño,

J. Branera,

Rodrigo Guerrero,

J Villalba,

Alejandro Rodríguez,

N. Berga,

Elena JiménezXarrié,

Gemma Romeral,

Ángel Ois,

Jordi Jiménez,

Carla Avellaneda-Gómez,

Núria Cayuela,

Ana Belén Rodríguez,

Eva Giralt,

Merçè Espona,

J. Saldaña,

David Hernández,

Marc Ribó,

Carlos Piñana,

Noelia Rodríguez,

Sandra Boned,

Carlos A. Molina,

Marta Rubiera,

Jesús Juega,

David RodríguezLuna,

Juan Pagola,

Alvaro Garcia-Tonel,

Matías Deck,

V. Sala,

Estela Sanjuán,

K. Santana,

C. Losada,

Pilar Suñé,

Tudor Jovin,

Enrique C. Leira,

José Ríos

Publication year - 2022

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2022.1645

Subject(s) - medicine , stroke (engine) , modified rankin scale , placebo , randomized controlled trial , occlusion , cardiology , ischemia , anesthesia , ischemic stroke , mechanical engineering , alternative medicine , pathology , engineering

It is estimated that only 27% of patients with acute ischemic stroke and large vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are disability free at 90 days. An incomplete microcirculatory reperfusion might contribute to these suboptimal clinical benefits.

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