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Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults
Author(s) -
Danni Li,
Angela Radulescu,
Rupendra T. Shrestha,
Matthew Root,
Amy B. Karger,
Anthony A. Killeen,
James S. Hodges,
Shu-Ling Fan,
Angela M. Ferguson,
Uttam Garg,
Lori J. Sokoll,
Lynn A. Burmeister
Publication year - 2017
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2017.13705
Subject(s) - medicine , ingestion , biotin , hormone , physiology , endocrinology , biochemistry , chemistry
Biotinylated antibodies and analogues, with their strong binding to streptavidin, are used in many clinical laboratory tests. Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults.

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