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Naaval Kottai Mathirai is a herbal Siddha preparation prepared from the seed of Syzygium cumini and leaf juice of Aristolochia bracheolata which is widely used in South India as traditional Siddha medicine for the treatment of diabetes mellitus (Madhumegam). The present study is aimed to investigate the acute and sub chronic toxicity of anti diabetic Siddha medicine Naaval Kottai Mathirai in healthy Wistar rats. In acute study, NKM (2000mg /kg) was administered to the wistar albino rats and observed for 14 days. For Sub chronic toxicity study the drug NKM was administered with the dose of LD 90 mgm, MD 450 mgm, HD 900 mgm for 90 days. The results of this study, the drug NKM neither produced significant changes in the consumption of food and intake of water , nor affected biochemical parameters, hematological parameters (full blood count) and histopathology studies . This study concluded that, the results revealed that the drug NKM at a dose of 2 g/kg was found to be toxicologically safe as a potent anti-hyperglycemic agent in Wistar rats.

Toxicological Evaluation of Anti- Diabetic Siddha Medicine Naaval Kottai Mathirai in Rat Model