English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Summary The aim of the study was to investigate and compare the effects of N-acetyl cysteine (NAC) and resveratrol on acute phase response in rats with experimentally induced arthritis. In this study, 30 Sprague-Dawley mature rats were inoculated with two doses of Freund’s Complete Adjuvant (FCA) by means of intradermal injections into the left hind claws of all rats. Rats were divided into three groups at the 15 th day of arthritis formation process, 15% ethyl alcohol was applied to group 1 rats via i.p., NAC was applied to group 2 rats via i.p. and resveratrol was applied to group 3 rats via i.p. for 21 days. Following the experimental period, blood was collected from the rats and then they were euthanized, and the joint tissues were collected. No significant differences were found in serum TNF-α, IL-1β, IL-6 levels and ADA activity and a decrease was determined in MDA levels in the resveratrol group. According to histopathological result, decreases in the loss of cellularity and adhesion were determined as P<0.05 and P<0.01, respectively in group received resveratrol. Compared to arthritis group, the decrease (P<0.05) in safranin-O ortochromatosis in group 2 and 3 was found. However the recovery from synovial inflammation (P<0.01) was determined both in NAC and resveratrol groups. The best recovery rate was recorded in the resveratrol group. In conclusion, resveratrol may be suggested to use in arthritis therapy alternative to NAC.

Investigation of the Effects of N-Acetyl Cysteine and Resveratrol to Acute Phase Response in Rats with Experimentally Induced Arthritis