The Protective Effect of Ellagic Acid Against Renal Ischemia-Reperfusion Injury in Male Rats | Zendy

Yaşar Bozkurt | Zendy; Uğur Fırat | Zendy; Murat Atar | Zendy; Ahmet Ali Sancaktutar | Zendy; Necmettin Pembegül | Zendy; Haluk Söylemez | Zendy; Hatice Yüksel | Zendy; Harun Alp | Zendy; Mehmet Nuri BODAKCI | Zendy; Namık Kemal Hatipoğlu | Zendy; Sadık Büyükbaş | Zendy

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The Protective Effect of Ellagic Acid Against Renal Ischemia-Reperfusion Injury in Male Rats

Author(s) -

Yaşar Bozkurt,

Uğur Fırat,

Murat Atar,

Ahmet Ali Sancaktutar,

Necmettin Pembegül,

Haluk Söylemez,

Hatice Yüksel,

Harun Alp,

Mehmet Nuri BODAKCI,

Namık Kemal Hatipoğlu,

Sadık Büyükbaş

Publication year - 2012

Publication title -

kafkas universitesi veteriner fakultesi dergisi

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.263

H-Index - 20

eISSN - 1309-2251

pISSN - 1300-6045

DOI - 10.9775/kvfd.2012.6517

Subject(s) - ellagic acid , ischemia , pharmacology , medicine , renal injury , reperfusion injury , kidney , antioxidant , chemistry , biochemistry , polyphenol

Summary The aim of this study was to evaluate the possible protective effect of ellagic acid (EA) on rats following renal ischemia–reperfusion (I/R) injury. Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 min without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 min of reperfusion. I/R+EA group were subjected to the same renal ischemia/reperfusion as the I/R group, were also given 85 mg/kg EA perorally 30 min prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. I/R damage significantly increased serum MDA levels in the I/R group when compared with Sham group. Serum TAC level was significantly lower in I/R group than I/R+EA group. A significantly increase on OSI levels and decrease on TAC levels was found in the kidneys in I/R group. In I/R + EA group, EA reversed the negative effects of I/R injury. EA pretreatment was effective in decreasing tubular necrosis score. In conclusion; EA pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.

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