Chronic Granulocytic Leukemia in a Dog, in Turkey

Myeloproliferative disease involves both acute and chronic leukaemias of the granulocytic and monocytic cell lines . Chronic granuloctytic leukemia (CGL), an uncommon myeloproliferative disorder resulting in substantial proliferation of mature granulocytes, may be characterised by the production of large numbers of mature differentiated neutrophil polymorphonuclear leucocytes . The most common physical findings of the disease are lethargy, pyrexia, hepatosplenomegaly and mild to moderate lymphadenopathy . The haemotological abnormalities may be indicative of potential myeloproliferative disease, within the presence of morphologically abnormal white blood cells. As a common entity there may be giant neutrophils, abnormal nuclear morphology, abnormal neutrophil granulation or evidence of neutrophil dysfunction despite adequate or increased neutrophil counts . When these abnormailities are observed, bone marrow aspiration and tissue biopsy should be performed in an attempt to make tentative diagnosis and intensive laboratory investigations may be required.