Open AccessLow Serum Interleukin-13 Levels Correlate with Poorer Prognoses for Colorectal Cancer Patients
Author(s) -
Susumu Saigusa,
Koji Tanaka,
Yasuhiro Inoue,
Yuji Toiyama,
Yoshinaga Okugawa,
Takashi Iwata,
Yasuhiko Mohri,
Masato Kusunoki
Publication year - 2014
Publication title -
international surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.132
H-Index - 39
eISSN - 2520-2456
pISSN - 0020-8868
DOI - 10.9738/intsurg-d-13-00259.1
Subject(s) - medicine , colorectal cancer , stage (stratigraphy) , lymphovascular invasion , gastroenterology , multivariate analysis , oncology , lymph node , cancer , metastasis , distant metastasis , disease , lymph node metastasis , interleukin , cytokine , lymphatic system , pathology , biology , paleontology
Interleukin-13 (IL-13) is an immunosuppressive cytokine produced by several immune cells and cancer cells. The aim of this retrospective study was to determine if serum IL-13 levels have an association with clinical outcome in patients with colorectal cancer. A total of 241 patients with colorectal cancer were enrolled in the present study. Preoperative serum IL-13 concentrations were measured by enzyme-linked immunosorbent assay. We analyzed the association of serum IL-13 levels with clinicopathological variables. Patients with lymph node metastasis, lymphatic invasion, vascular invasion, distant metastases or advanced stage of disease had significantly lower serum IL-13 levels. Low serum IL-13 was significantly associated with both poor recurrence-free and overall survival. Multivariate analysis showed that low IL-13 levels were an independent predictive marker for poor prognosis. In conclusion, our data suggest that low serum IL-13 levels may be a useful predictive marker for poor prognosis in colorectal cancer.
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