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Aims: This study was aimed at comparing the physicochemical and bioavailability profilesof some brands of Levofloxacin 500mg tablets that are registered in Nigeria by herregulatory authority and to examine the feasibility of interchangeability of the brands.Methodology: The physicochemical equivalence of ten brands of Levofloxacin 500 mgtablets (LEV-1 to LEV-10) were evaluated using both official and unofficial standardsincluding weight variation, hardness, friability test, chemical assay, disintegration,dissolution rate and drug content. Five of the brands were also evaluated forbioavailability profiles using a single dose randomized two period cross–over designsmeasuring the concentration of drugs in the urine. Urinary samples before dosing and atvarious appropriate time intervals up to 12 hours were analyzed by validated DoubleBeam U. V. Spectrophotometer method with 99.8% extraction recovery. Pharmacokineticparameters for bioequivalence evaluation C

Physicochemical and Bioequivalence Studies on Some Brands of Levofloxacin Tablets Registered in Nigeria