Human Bone Marrow Subpopulations Sustain Human Islet Function and Viability In vitro | Zendy

Lu Luo | Zendy; Fang Xiong | Zendy; Philippe Ravassard | Zendy; John Z.Q. Luo | Zendy

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Human Bone Marrow Subpopulations Sustain Human Islet Function and Viability In vitro

Author(s) -

Lu Luo,

Fang Xiong,

Philippe Ravassard,

John Z.Q. Luo

Publication year - 2015

Publication title -

british journal of medicine and medical research

Language(s) - English

Resource type - Journals

ISSN - 2231-0614

DOI - 10.9734/bjmmr/2015/17536

Subject(s) - islet , cell sorting , bone marrow , population , progenitor cell , biology , regeneration (biology) , microbiology and biotechnology , transplantation , stem cell , immunology , cell , flow cytometry , medicine , endocrinology , diabetes mellitus , genetics , environmental health

Allogeneic bone marrow (BM) has been shown to support human islet survival and function in long-term culture by initiating human islet vascularization and β-cell regeneration. Various BM subpopulations may play different roles in human islet functions and survival. In this paper we investigated the effects of BM and its subpopulations, endothelial progenitor cells (E) and mesenchymal (M) cells on human islet's β-cell function and regeneration.

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