Cudrania tricuspidata Root Extract as Whitening and Antiwrinkle Cosmetic Agent

Water extracts of root, leaf, branch and fruit of Cudrania tricuspidata were tested to use as natural anti- wrinkle and whitening cosmetic ingredient. Root extract indicated 86.5 mg/g polyphenol concentration and 55.5 mg/g flavonoid concentration. From MTT test, root, branch and fruit extract did not show cell toxicity up to 1,000 µg/mL, however, leaf extract displayed significant cell toxicity in concentrations higher than 200 µg/mL. Cudrania tricuspidata root extracts displayed excellent 81% tyrosinase inhibition (whitening effect), 58% elastase inhibition (antiwrinkle effect) at 500 µg/mL and showed minor UVB absorbance. When solution and lotion formulation were made including Cudrania tricuspidata root extract, they are stable at 25 o C for 21 days, but showed significant deviation in viscosity and particle size at 47 o C. From the study, Cudrania tricuspidata root extract demonstrated good potential for natural whitening and