Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation. | Zendy

Adolfo RamirezZamora | Zendy; Brian C. Kaszuba | Zendy; Lucy Gee | Zendy; Julia Prusik | Zendy; Fabio Danisi | Zendy; Damian S. Shin | Zendy; Julie G. Pilitsis | Zendy

Open Access

Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation.

Author(s) -

Adolfo RamirezZamora,

Brian C. Kaszuba,

Lucy Gee,

Julia Prusik,

Fabio Danisi,

Damian S. Shin,

Julie G. Pilitsis

Publication year - 2016

Publication title -

doaj (doaj: directory of open access journals)

Language(s) - English

Resource type - Journals

ISSN - 2160-8288

DOI - 10.7916/d8s182jj

Subject(s) - deep brain stimulation , local field potential , dystonia , globus pallidus , refractory (planetary science) , essential tremor , neuroscience , stimulation , refractory period , medicine , physical medicine and rehabilitation , psychology , basal ganglia , anesthesia , parkinson's disease , physics , central nervous system , disease , astrobiology

Background: Holmes tremor (HT) is an irregular, low-frequency rest tremor associated with prominent action and postural tremors. Currently, the most effective stereotactic target and neurophysiologic characterization of HT, specifically local field potentials (LFPs) are uncertain. We present the outcome, intraoperative neurophysiologic analysis with characterization of LFPs in a patient managed with left globus pallidus interna deep brain stimulation (Gpi DBS).

Case Report: A 24-year-old male underwent left Gpi DBS for medically refractory HT. LFPs demonstrated highest powers in the delta range in Gpi. At the 6-month follow-up, a 90% reduction in tremor was observed.

Discussion: Pallidal DBS should be considered as an alternative target for management of refractory HT. LFP demonstrated neuronal activity associated with higher power in the delta region, similarly seen in patients with generalized dystonia.

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