FORMULATION DEVELOPMENT AND EVALUATION OF LIPOSOMAL GEL FOR THE TREATMENT OF ULCERATIVE COLITIS

The present objective for the study as to prepare mesalazine liposomal gel intended for the treatment and management of ulcerative colitis. The aim of this project has been to develop liposomal drug carrier system, able to provide sustained and controlled release of Mesalazine for local rectal therapy. Various liposome formulation was prepared by the thin film hydration technique by using vacuum rotator evaporator by varying the lipid phase composition (lecithin/cholesterol) and evaluated drug content, Particle size analysis, Zeta (z) potential measurement, entrapment efficacy. Liposomal vesicles with good entrapment efficiencies were in corporated in carbopol gel base was evaluated for pH, viscosity, drug content, in-vitro drug release study. Results of all studies suggested that mesalazine liposomal gel formulation was therapeutically effective drug delivery system for treatment of ulcerative colitis.