ROLE OF NARINGIN ON GEMCITABINE-INDUCED LIPID PEROXIDATION

Aim: The aim of the present study was to investigate the antiperoxidative property of naringin on gemcitabine-induced lipid peroxidation. Methods: The in vitro work was carried out using goat liver as model lipid source. Two common laboratory markers such as malondialdehyde and reduced glutathione were used for the model. Results: The data generated from the work showed that gemcitabine increase the MDA level and reduce the GSH level. But when gemcitabine was used in combination with naringin then there is decrease in MDA level and increase in GSH level. Conclusion: The results showed that gemcitabine has the ability to induce lipid peroxidation to a significant extent and it was also found that naringin has antiperoxidative potential to suppress the gemcitabine-induced toxicity.