KINETICS AND MECHANISM OF PERMANGANATE OXIDATION OF ENROFLOXACIN IN AQUEOUS ALKALINE MEDIUM

The reaction kinetics of oxidation of enrofloxacin by potassium permanganate has been investigated in aqueous alkaline medium using spectrophotometric technique at 30 ± 1°C at constant ionic strength of 0.10 mol L -1 . The reaction exhibits 2:1 stoichiometry (2 KMnO4:1 Enrofloxacin). The order with respect to oxidant and substrate is found to be unity in each, whereas fractional order with respect to alkali concentration. The oxidation products were identified by using FTIR, LCMS spectral studies. The effects of added products, ionic strength and dielectric constant have been studied on the rate of reaction. Based on the experimental results a suitable mechanism is proposed. There is no evidence of intermediate complex formation, thus, the outer-sphere mechanism is proposed as the mechanism for this reaction.