PACLITAXEL INDUCED LIPID PEROXIDATION: ROLE OF WATER EXTRACT OF SPIRULINA PLATENSIS | Zendy

Supratim Ray | Zendy; Sarbani Dey Ray | Zendy

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PACLITAXEL INDUCED LIPID PEROXIDATION: ROLE OF WATER EXTRACT OF SPIRULINA PLATENSIS

Author(s) -

Supratim Ray,

Sarbani Dey Ray

Publication year - 2016

Publication title -

journal of pharmaceutical and scientific innovation

Language(s) - English

Resource type - Journals

ISSN - 2277-4572

DOI - 10.7897/2277-4572.0518

Subject(s) - spirulina (dietary supplement) , lipid peroxidation , malondialdehyde , paclitaxel , chemistry , toxicity , in vitro , biochemistry , food science , pharmacology , biology , antioxidant , medicine , chemotherapy , organic chemistry , raw material

The present study showed th e free radical scavenging activity of water extract of Spirulina platensis on paclitaxel - induced lipid peroxidation. This in vitro work was carried out with goat liver as lipid source using malondialdehyde and 4 - hydroxy - 2 - nonenal as model markers. The find ings suggest that paclitaxel could induce lipid peroxidation to a significant extent and it was also found that water extract of the Spirulina platensis has the ability to suppress the paclitaxel - induced toxicity.

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