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Poly pharmacy significantly raises the likelihood of adverse reac tions to drugs, risk of hospitalization and medical errors related to drugs. It depends on the number of drugs, the diseases, and patient related factors . Poly pharmacy is a risk factor for severe adverse drug reactions (ADRs) and is associated with an inc reased risk of mortality. The main aim of the study was to assess the poly pharmacy leading to adverse drug reaction. This is a prospective observational study conducted at Basaveshwara Medical College Hospital and Research Center (BMCH and RC), Chitradurg a , India for the period of 4 months in the department of Medicine. In this study 601 patients of both genders were included. The identified ADRs are reported to the phy sician and causality assessment of adverse drug reactions (ADR’s) was done by using the Naranjo’s scale and Modified Hartwig Seigle scale. About 601 patients screened among them 315 patients were males and 286 were females and average drugs per prescription were 6.17. There are 356 (59.23 %) patients with major poly pharmacy ( ≥ 6 drugs) and 2 45 (40.76 %) with minor poly pharmacy (3 - 5 drugs). During the study 32 ADRs were identified and reported to the Physicians; in this 28 ADRs were accepted. The prevalence of ADRs seen during the study was 5.32 % and in this 3.49 % (n = 21) were seen patien ts who had major poly pharmacy. Our study showed that females were more prone to develop ADRs compared to the males i.e., 53.12 % (n = 17) of ADRs were identified in female gender and 46.87 % (n = 15) in male gender. Out of 32 ADRs 21 (65.62 %) were identi fied in patients with major poly pharmacy and 11 (34.37 %) with minor poly pharmacy. There were more ADRs associated with major poly pharmacy and female gender. It is necessary to create the awareness to curb irrational prescription of poly pharmacy which helps in prevention of drug related problems like ADRs.

A PROSPECTIVE OBSERVATIONAL STUDY ON POLYPHARMACY LEADING TO ADVERSE DRUG REACTIONS IN A DEPARTMENT OF MEDICINE