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The treatment option for AIDS have drastically changed since 1987 when the first drug of HIV/AIDS Zidovudin (ZDV) was approv ed, mono therapy has been replaced by the most effective currently is HAART which includes three drugs from one or all th e three categories to decrease incidence of viral resistance. From about, 1,387,039 people living with HIV/AIDS in Ethiopia 167,271 peo ple were initiated on ART by October 2009. The aim of this study is to determine comparative effects of ART on CD4 + cell count in Jimma University Specialized Hospital and assess comparative effects of ZDV and d4T based combinations on CD4 + cell count, to assess comparative effects of EFV and NVP based combinations on CD4 + cell count. Cross - sectional retrospecti ve study was employed . Data (from June 2006 to October 1, 2013) was collected from patient records using data collection format to determine compara tive effects of ART regimen on CD4 + cell count in Jimma university specialized hos p ital . One hundred twenty three patients fulfilled the inclusion criteria and were studied. At six month the EFV based regimens CD 4 + cell count had increased with mean of 332 cells/mm 3

journal of pharmaceutical and scientific innovation

COMPARATIVE STUDY OF THE EFFECTS OF ANTIRETROVIRAL THERAPY (ART) ON CD4 CELL COUNT IN JIMMA UNIVERSITY SPECIALIZED HOSPITAL, JIMMA TOWN, OROMIA REGION, ETHIOPIA