ANALGESIC EVALUATION OF NOVEL ANTICONVULSANT WITH A CONVENTIONAL ANALGESIC IN DUAL PAIN MODEL OF RAT | Zendy

Dhanesh Kumar | Zendy; Saurabh Kansal | Zendy; Priti Saxena | Zendy; Kalpana Chauhan | Zendy; Abhishek Aggarwal | Zendy

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ANALGESIC EVALUATION OF NOVEL ANTICONVULSANT WITH A CONVENTIONAL ANALGESIC IN DUAL PAIN MODEL OF RAT

Author(s) -

Dhanesh Kumar,

Saurabh Kansal,

Priti Saxena,

Kalpana Chauhan,

Abhishek Aggarwal

Publication year - 2014

Publication title -

journal of pharmaceutical and scientific innovation

Language(s) - English

Resource type - Journals

ISSN - 2277-4572

DOI - 10.7897/2277-4572.033150

Subject(s) - analgesic , anticonvulsant , medicine , anesthesia , pharmacology , analgesic agents , epilepsy , psychiatry

G abapentin and carbamazepine like anti epileptics a re being used now a days to treat a number of disease s associated with neuropathic pain. The aim of this stu dy is to observe whether novel anticonvulsants are able to pro duce analgesic response in pain conditions of acute and chronic type . This study observed the analgesic effect of lamo trigine in rats by bi phasic noci ceptive pain model of formalin test and compared its potency with a convention al opioid analgesic tramadol. Per oral adminis tration of l amotrigine produced no s i gnificant effect on early phase response of formalin test but significantly suppress ed the late phase response. We conclude that lamotrigine has antinociceptive effect in chronic inflammatory pain as seen by its effect on late phase of f ormalin test while

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