ACUTE ORAL TOXICITY STUDIES OF VITIS VINIFERA (GRAPES) PRODUCED BY MICROBIAL FERTIGATION AND FOLIAR SPRAY OF PANCHAGAVYA

Acute oral toxicity of organic grapes produced by microbial f ertigation and foliar spray of p anchagavya was evaluated in a lbino rat s. In the present study, albino wistar rats were administered Vitis vinifera fruit extract orally with dosages of 200, 400 and 800 mg Kg - 1 body weight. Mortality, body weight and haematological parameters w ere observed for 7 day s after treatment. E ffect of m ethanolic extract of Vitis vinifera on pylorus ligated rats and HCl – Ethanol induced gastric lesion in rats was studied simultaneously . The methanol extract of Vitis vinifera was found to be non toxic and safe as oral intake. The m ethanol extract of organic grapes was found to possess a protective effect again s t gastric ulcer and ac idit y.