SYNTHESIS OF N-METHYLATED ANALOG OF AMIDOMYCIN: A POTENT ANTIMICROBIAL CYCLOHEPTAPEPTIDE | Zendy

M. Himaja | Zendy; Ogale Sachin Ramachandra Rao | Zendy; Moonjit Das | Zendy; Karigar Asif | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

SYNTHESIS OF N-METHYLATED ANALOG OF AMIDOMYCIN: A POTENT ANTIMICROBIAL CYCLOHEPTAPEPTIDE

Author(s) -

M. Himaja,

Ogale Sachin Ramachandra Rao,

Moonjit Das,

Karigar Asif

Publication year - 2014

Publication title -

journal of pharmaceutical and scientific innovation

Language(s) - English

Resource type - Journals

ISSN - 2277-4572

DOI - 10.7897/2277-4572.033142

Subject(s) - triethylamine , antimicrobial , bacteria , chemistry , peptide , stereochemistry , minimum inhibitory concentration , cyclic peptide , base (topology) , proton nmr , combinatorial chemistry , organic chemistry , biochemistry , biology , mathematical analysis , genetics , mathematics

N - methylated analog of Amidomycin, was synthesized by solution phase peptide synthesis using dicyclohexylcarbodiimide (DCC) as the coupling agent and triethylamine (TEA) as the base. T he structure of the compound was confirmed by IR, 1 H NMR, 13 C NMR, FABMASS and elemental analysis. T he synthesiz ed cyclic peptide was evaluated for Minimum Inhibitory Concentration (MIC) against four strains of bacteria and three strains of fungi. It was f ound to be active against both bacteria and fungi from 50 - 100 μ g.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research