STABILITY INDICATING THIN LAYER CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PAMABROM IN BULK AND COMBINED PHARMACEUTICAL DOSAGE FORM | Zendy

Dhruvi R Shah | Zendy; Himani N Patel | Zendy; Bhagirath Patel | Zendy; Ankita Bhavsar | Zendy

Open Access

STABILITY INDICATING THIN LAYER CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PAMABROM IN BULK AND COMBINED PHARMACEUTICAL DOSAGE FORM

Author(s) -

Dhruvi R Shah,

Himani N Patel,

Bhagirath Patel,

Ankita Bhavsar

Publication year - 2014

Publication title -

journal of pharmaceutical and scientific innovation

Language(s) - English

Resource type - Journals

ISSN - 2277-4572

DOI - 10.7897/2277-4572.032132

Subject(s) - chromatography , high performance thin layer chromatography , chloroform , acetonitrile , chemistry , pharmaceutical formulation , thin layer chromatography , dosage form , reagent , organic chemistry

A simple stability indicating thin layer chromatographic method was developed for simultaneous estimation o f Paracetamol and Pamabrom in bulk and combined pharmaceutical dosage form. Thin layer chromatography was performed, using a mixture of Chloroform: Acetonitrile (5:5 v/v) as a mobile phase . The R f value for Paracetamol a nd Pamabrom was found to be 0.66 and 0. 6 5 respectively. Paracetamol and Pamabrom were subjected to stress conditions including acidic, alkaline, oxidation, thermal and sunlight degradation. The method was validated as per International conference harmonization ( ICH ) guidelines.

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