HOMOLOGY MODELLING, VALIDATION AND DOCKING OF DFHR WITH BREAST CANCER INHIBITORS | Zendy

Shailima Rd Vardhini | Zendy

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HOMOLOGY MODELLING, VALIDATION AND DOCKING OF DFHR WITH BREAST CANCER INHIBITORS

Author(s) -

Shailima Rd Vardhini

Publication year - 2014

Publication title -

journal of pharmaceutical and scientific innovation

Language(s) - English

Resource type - Journals

ISSN - 2277-4572

DOI - 10.7897/2277-4572.032129

Subject(s) - docking (animal) , breast cancer , computational biology , homology modeling , biology , medicine , genetics , biochemistry , cancer , veterinary medicine , enzyme

Proteins are the biomolecules which have a vital role in the human beings. The biological activity of the proteins is based o n the structures of the proteins. One of the structural import ance of the proteins is making the proteins a validate drug targets . In the present article DHFR enzyme structure was predicted and validated. Further the experiment proceeds by performing the docking studies of this modeled structure with Breast cancer in hibitors giving a scope for one drug many cancer concept. The docking results were very promising with the H - bond interactions between Gly118, Gly21, Lys 56, Thr 147 and Asp 22.

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