WOUND HEALING ACTIVITY OF VARIOUS EXTRACTS OF FRUIT OF PYRUS COMMUNIS L. IN NORMAL RATS

To evaluate the fruit of Pyrus communis L. for its wound healing property by dif ferent wound models using wistar albino rats. The wound healing activity of ethyl acetateandethanol extracts of fruits of Pyrus communis (EAEPC and EEPC 200 mg/kg) was investigated by various wound healing model in normal rats such as excision, incision an d dead space wound model. Povidone iodine is used as standard. The wound was created according to standard procedure in different model and the wound contraction area, epithelization period , scar area , breaking strength and weight of granuloma were assessed . The phytochemical screening and total phenolic content was estimated in both extracts. Hydroxyproline content of harvested granulation tissue was estimated in all groups of animals. The result suggests various extracts of Pyrus communis have significant (p < 0.01) wound healing activity in different models . In this study we concluded that fruit of Pyrus communis is natural remedy for treating different type of wounds .