ANTI-MICROBIAL EVOLUTION OF NOVEL THIAZOLES

A vast array of thiazole derivatives having excellent broad spectrum activity forms an invaluable part of the present armory of the clinicians. A novel series of th iazole compounds were synthesized and screened for the anti - bacterial and anti - fungal activity. The structures of these compounds were ascertained by IR H 1 NMR, mass spectra and elemental analysis. The anti - bacterial activity of the synthesized compounds w ere evaluated against gram positive bacte ria and gram negative bacteria all the compounds had shown moderate to sign ificant anti - bacterial activity . The anti - fungal activity of the compounds is more significant than anti - bacterial activity.