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The current research paper reports a validated UV and RP - HPLC method fo r routine estimations of CFTX in bulk and unit dosage formulations. For the UV estimation of CFTX, using ammonium acetate buffer as the solvent, λ max was set at 241.5 nm and linearity range obtained in the concentration range of 2 - 10 µg/mL. The optimized R P - HPLC conditions for CFTX estimation were obtained with isocratic separation mode in a C 18 inertsil column (150 mm × 4.6 mm, 3 μm) using a degassed mixture of buffer: methanol in the ratio of 74:26, injection volume (20 µL), flow rate (1 mL/min) and ru n t ime (20 min utes ), at ambient column temperature with UV detector set at 254 nm. The linearity of the method was demonstrated over the concentration range of 80 - 120 µg/mL. The percent assay of CFTX determined by UV and RP - HPLC method were 99.8 ± 0.001 and 1 01.5 ± 0.001 respectively. The recovery CFTX deter mined by UV and RP - HPLC were 99 .6 - 99.8 % and 101.1 % respectively with % RSD values of peak areas 0.2 and 0.3 respectively. Values of all other parameters of method validations in both methodologies were wi thin the acceptance limits.

DEVELOPMENT AND VALIDATION OF UV AND RP-HPLC METHODS FOR THE ESTIMATION OF CEFTRIAXONE SODIUM IN PHARMACEUTICAL FORMULATIONS