A NOVEL VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF BETAMETHASONE USING OXIDATION APPROACH | Zendy

Fathi H. Assaleh | Zendy; Shaban G Elosta | Zendy; Fathi M Asseid | Zendy; Babu Rao Chandu | Zendy; Prakash Katakam | Zendy

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A NOVEL VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF BETAMETHASONE USING OXIDATION APPROACH

Author(s) -

Fathi H. Assaleh,

Shaban G Elosta,

Fathi M Asseid,

Babu Rao Chandu,

Prakash Katakam

Publication year - 2013

Publication title -

journal of pharmaceutical and scientific innovation

Language(s) - English

Resource type - Journals

ISSN - 2277-4572

DOI - 10.7897/2277-4572.02567

Subject(s) - betamethasone , estimation , mathematics , chromatography , chemistry , medicine , engineering , systems engineering

A simple, sensitive, rapid and accurate spectrophotometric method was developed and validated for the estimation of betamethasone in bulk and pharmaceutical dosage forms. The method was based on the formation of bluish green chromophore with 0.04 % of sodium dichromate and concentrated sulphuric acid showing the absorption at 615 nm. The proposed method has permitted the quantification of betamethasone over linearity in the range of 5 30 µg/mL. The method was validated as per ICH guidelines

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