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Objective: The purpose of the present work was to enhance antimicrobial activity of Suppress release Amoxicillin Camphor complexed Mucoadhesive tablets by Statistical Experimental Design using Sigma tech software version 3.1. Amoxicillin has short half-life (1 h) which requires frequent administration of the conventional amoxicillin tablets and is mainly used in the eradication of Helicobacter pylori that resides in the stomach. Methods: Amoxicillin-Sodium cholate (ASC) and camphor complexes (ACC) were prepared to enhance antimicrobial activity. Results: TLC and FT-IR studies confirmed the formation of drug complex. Zone of inhibition by agar well diffusion method of ACC showed greater inhibition than ASC, solubility of ACC was enhanced by re-crystallization technique. Hence ACC needle shaped re-crystallized was used to sustained release tablets using mucoadhesive polymers. Chitosan, HPMC K-15 and Ethyl cellulose (EC) were selected as independent variables and ex vivo mucoadhesion time, % drug release at 24 h and t 50 % (time to release 50 % drug) were selected as dependent variables. DSC studies indicated drug and excipients were compatible. Swelling studies and scanning electron microscopic analysis confirmed the drug release mechanism from sustained release tablets. In-vitro release studies and ex vivo studies of amoxicillin confirmed the sustained drug release profile with first order release kinetics better mucoadhesion and enhanced antimicrobial activity. The optimized formulation was found to be stable at accelerated storage conditions for 3 months. Conclusion: The results demonstrated the effectiveness of the proposed statistical design for optimization of ACC sustained release tablets.

ENHANCEMENT OF ANTIMICROBIAL ACTIVITY OF SUPPRESS RELEASE AMOXICILLIN CAMPHOR COMPLEXED MUCOADHESIVE TABLETS BY STATISTICAL EXPERIMENTAL DESIGN