Disseminated Herpes Simplex Masquerading as Hemophagocytic Lymphohistiocytosis: A Case Report | Zendy

David Liew | Zendy; B Jones | Zendy; Alan J. Hunter | Zendy

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Disseminated Herpes Simplex Masquerading as Hemophagocytic Lymphohistiocytosis: A Case Report

Author(s) -

David Liew,

B Jones,

Alan J. Hunter

Publication year - 2019

Publication title -

the permanente journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.445

H-Index - 30

eISSN - 1552-5775

pISSN - 1552-5767

DOI - 10.7812/tpp/18-202

Subject(s) - medicine , hemophagocytic lymphohistiocytosis , differential diagnosis , fulminant , herpes simplex virus , sepsis , hepatitis , pediatrics , immunology , encephalitis , disease , pathology , virus

Marked elevation in serum ferritin levels may be seen in disseminated infection or severe organ failure states, but it is also present in hemophagocytic lymphohistiocytosis (HLH). Herpes simplex virus (HSV) hepatitis has a high mortality rate, even in immunocompetent individuals, in whom it is rarely reported. We present a case of hyperferritinemia with features initially suggestive of a diagnosis of HLH but that ultimately proved to be fulminant HSV hepatitis.

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