Myocardial Infarction and Its Association with the Use of Nonselective NSAIDs: A Nested Case-Control and Time-to-Event Analysis | Zendy

T Craig Cheetham | Zendy; David J. Graham | Zendy; David Campen | Zendy; Rita L. Hui | Zendy; Michele M. Spence | Zendy; Gerald Levy | Zendy; Stanford Shoor | Zendy

Open Access

Myocardial Infarction and Its Association with the Use of Nonselective NSAIDs: A Nested Case-Control and Time-to-Event Analysis

Author(s) -

T Craig Cheetham,

David J. Graham,

David Campen,

Rita L. Hui,

Michele M. Spence,

Gerald Levy,

Stanford Shoor

Publication year - 2008

Publication title -

the permanente journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.445

H-Index - 30

eISSN - 1552-5775

pISSN - 1552-5767

DOI - 10.7812/tpp/07-081

Subject(s) - medicine , rofecoxib , nested case control study , odds ratio , confidence interval , myocardial infarction , population , pharmacoepidemiology , adverse effect , adverse event reporting system , emergency medicine , cyclooxygenase , pharmacology , environmental health , biochemistry , chemistry , medical prescription , enzyme

In April 2005, the US Food and Drug Administration issued a public health advisory warning to health care clinicians about the cardiovascular (CV) safety of nonsteroidal anti-inflammatory drugs (NSAIDs). Although the warning about cyclooxygenase-2 selective NSAIDs was anticipated, little data exists about the CV safety of nonselective NSAIDs. We analyzed data from a group of NSAID users to determine if specific nonselective agents were associated with an increased risk of myocardial infarctions (MIs) and sudden cardiac death (SCD).

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