Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia? | Zendy

Moneeb A. K. Othman | Zendy; Amelie Lier | Zendy; Susann Junker | Zendy; Philipp Kempf | Zendy; Franziska Dorka | Zendy; Erich Gebhart | Zendy; Frenny Sheth | Zendy; Beata Grygalewicz | Zendy; Samarth Bhatt | Zendy; Anja Weise | Zendy; Kristin Mrasek | Zendy; Thomas Liehr | Zendy; Marina Manvelyan | Zendy

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Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia?

Author(s) -

Moneeb A. K. Othman,

Amelie Lier,

Susann Junker,

Philipp Kempf,

Franziska Dorka,

Erich Gebhart,

Frenny Sheth,

Beata Grygalewicz,

Samarth Bhatt,

Anja Weise,

Kristin Mrasek,

Thomas Liehr,

Marina Manvelyan

Publication year - 2012

Publication title -

biodiscovery

Language(s) - English

Resource type - Journals

ISSN - 2050-2966

DOI - 10.7750/biodiscovery.2012.4.2

Subject(s) - interphase , myeloid leukemia , chromosomal translocation , fluorescence in situ hybridization , bone marrow , biology , cancer research , chromosome , myeloid , genetics , gene , immunology

The impact of chromosome architecture in the formation of chromosome aberrations is a recent finding of interphase directed molecular cytogenetic studies. There evidence was provided that disease specific chromosomal translocations could be due to tissue specific genomic organization. In a recent small pilot study using three-dimensional interphase fluorescence in situ hybridization, we showed that there might be a specific chromosome positioning in myeloid bone marrow cells, i.e. a co-localization of chromosomes 8 and 21. Here we could substantiate this finding in overall 21 studied cases with acute myeloid leukemia (AML) that there is even a co-localization of the genes AML1 and ETO. This finding led to the suggestion that a specific interphase architecture of myeloid bone marrow cells might promote the typical t(8;21)(q22;q22) leading to AML-M2

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